The gut microbiota has been recognized as an important determinant in the initiation and
progression of colorectal cancer (CRC), with recent studies shining light on the molecular …

Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Immunotherapy is one of the fastest developing areas in the field of oncology. Many
immunological treatment strategies for refractory tumors have been approved and marketed …

Host-microbiome-dietary interactions play crucial roles in regulating human health, yet their
direct functional assessment remains challenging. We adopted metagenome-informed …

Background The pathogenesis of non-alcoholic fatty liver disease (NAFLD) with a global
prevalence of 30% is multifactorial and the involvement of gut bacteria has been recently …

The gut fungal community represents an essential element of human health, yet its
functional and metabolic potential remains insufficiently elucidated, largely due to the limited …

Crohn's disease (CD) is a chronic and progressive inflammatory disease that can involve
any part of the gastrointestinal tract. The protective role of dietary polyphenols has been …

Colorectal cancer (CRC) screening relies primarily on stool analysis to identify occult blood.
However, its sensitivity for detecting precancerous lesions is limited, requiring the …

Background & Aims Inflammatory bowel disease is associated with carcinogenesis, which
limits the prognosis of the patients. The local expression of proteinases and proteinase …

Background Serrated lesions and polyps (SP) are precursors of up to 30% of colorectal
cancers (CRC) through the serrated pathway. This often entails early BRAF mutations and …