Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

The intestinal epithelium forms a highly dynamic and selective barrier that controls
absorption of fluid and solutes while restricting pathogen access to underlying tissues …

Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

The tight junction creates an intercellular barrier limiting paracellular movement of solutes
and material across epithelia. Currently many proteins have been identified as components …

Understanding of tight junctions has evolved from their historical perception as inert solute
barriers to recognition of their physiological and biochemical complexity. Many proteins are …

Cell surface receptors integrate chemical and mechanical cues to regulate a wide range of
biological processes. Integrin complexes are the mechanotransducers between the …

Epithelial transport relies on the proper function and regulation of the tight junction (TJ),
other‐wise uncontrolled paracellular leakage of solutes and water would occur. They also …

▪ Abstract Tight junctions form continuous intercellular contacts controlling solute movement
through the paracellular pathway across epithelia. Paracellular barriers vary among …

Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism
and its environment. Continuing studies have highlighted the regulation of the tight junction …

Breakdown of the blood-brain barrier (BBB) is an early and significant event in CNS
inflammation. Astrocyte-derived VEGF-A has been implicated in this response, but the …