The most significant advance in the medical management of HIV-1 infection has been the
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …

Viral fitness is an active area of research, with recent work involving an expanded number of
human, non-human vertebrate, invertebrate, plant, and bacterial viruses. Many publications …

The AIDS pandemic that started in the early 1980s is due to human immunodeficiency virus
type 1 (HIV-1) group M (HIV-M), but apart from this major group, many divergent variants …

The majority of the drugs currently used for the treatment of HIV infections (AIDS) belong to
either of the following three classes: nucleoside reverse transcriptase inhibitors (NRTIs) …

Maraviroc (MVC) is a CCR5 antagonist that inhibits HIV-1 entry by binding to the coreceptor
and inducing structural alterations in the extracellular loops. In this study, we isolated MVC …

One of the major factors contributing to HIV-1 drug resistance is suboptimal adherence to
combination antiretroviral therapy (cART). Currently, recommended cART for HIV-1 …

For the last thirty years, ongoing efforts have revolutionized the antiretroviral therapy, which
changed human immunodeficiency virus (HIV) infections from terrifying lethal diseases to …

Background Due to the prevalence of HIV-1 group M and the endemicity of HIV-1 group O
infections in Cameroon, patients may be infected with both viruses and/or with HIV-1/MO …

Twenty-five years ago, an aberrant HIV-1 (now classified as HIV-1 group O) was described
from a Cameroonian HIV patient living in Belgium. The epicenter of group O was later found …

Unlike the pandemic form of HIV-1 (group M), group O viruses are endemic in west central
Africa, especially in Cameroon. However, little is known about group O's genetic evolution …