Recent investigations have revealed that changes in DNA methylation status play an
important role in aging-associated pathologies and lifespan. The methylation of DNA is …

The Danish Twin Registry (DTR) was established in the 1950s, when twins born from 1870
to 1910 were ascertained, and has since been extended to include twins from birth cohorts …

Background The epigenetic landscape underlying cardiovascular disease (CVD) is not
completely understood and the clinical value of the identified biomarkers is still limited. We …

Background Epigenetic changes may result from the interplay of environmental exposures
and genetic influences and contribute to differences in age‐related disease, disability, and …

Biobank research may lead to an improved understanding of disease etiology and advance
personalized medicine. Denmark (population~ 5.9 million) provides a unique setting for …

DNA methylation (DNAm) has been reported to be associated with many diseases and with
mortality. We hypothesized that the integration of DNAm with clinical risk factors would …

Aim: Prostate cancer (PCa) is the most common malignancy found in males worldwide.
Although it is mostly indolent, PCa still poses a serious threat to long-term health. Materials …

Background Large numbers of autosomal sites are found differentially methylated in the
aging genome. Due to analytical difficulties in dealing with sex differences in X-chromosome …

Background Measures based on DNA methylation, epigenetic clocks, have recently gained
attraction as predictors of mortality and age-related pathologies. However, the origins of …

Background Tobacco smoking is a well-known modifiable risk factor for many chronic
diseases, including cardiovascular disease (CVD). One of the proposed underlying …