Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia

H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Early human trophoblast development: from morphology to function

M Gauster, G Moser, S Wernitznig, N Kupper… - Cellular and Molecular …, 2022 - Springer
Human pregnancy depends on the proper development of the embryo prior to implantation
and the implantation of the embryo into the uterine wall. During the pre-implantation phase …

The universe of galectin-binding partners and their functions in health and disease

MF Troncoso, MT Elola, AG Blidner, L Sarrias… - Journal of Biological …, 2023 - ASBMB
Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

Galectins in early pregnancy and pregnancy-associated pathologies

M Jovanović Krivokuća, A Vilotić… - International Journal of …, 2021 - mdpi.com
Galectins are a family of conserved soluble proteins defined by an affinity for β-galactoside
structures present on various glycoconjugates. Over the past few decades, galectins have …

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/β-catenin signaling to alleviate preeclampsia

Z Yang, X Jia, Q Deng, M Luo, Y Hou, J Yue… - International …, 2023 - Elsevier
Background Failures in invasive extravillous trophoblasts (EVTs) migration into the maternal
uterus have been noticed in preeclampsia (PE). Human umbilical cord mesenchymal stem …

Considerations to model heart disease in women with preeclampsia and cardiovascular disease

C Liu Chung Ming, K Sesperez, E Ben-Sefer, D Arpon… - Cells, 2021 - mdpi.com
Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of
gestation, and is the leading cause of death for both mothers and babies in pregnancy. The …

Chrysin-loaded calixarene-cyclodextrin ternary drug delivery system inhibits TGF-β and galectin-1 mediated pathways in diabetic liver fibrosis

C Balta, H Herman, A Ciceu, CC Lepre, B Mladin… - Biochemical …, 2024 - Elsevier
This study investigated the efficacy of a new chrysin-loaded calixarene-cyclodextrin ternary
drug delivery system (DDS) in reversing liver fibrosis in a mouse model of chronic diabetes …

Current understanding of the pathogenesis of placenta accreta spectrum disorder with focus on mitochondrial function

H Kobayashi, S Matsubara, C Yoshimoto… - Journal of Obstetrics …, 2024 - Wiley Online Library
Aim The refinement of assisted reproductive technology, including the development of
cryopreservation techniques (vitrification) and ovarian stimulation protocols, makes frozen …

Mechanical forces on trophoblast motility and its potential role in spiral artery remodeling during pregnancy

B Xie, H Wu, J Li, X Lv, Y Zhou, Q Yu, S Cui, L Zeng… - Placenta, 2022 - Elsevier
During the first trimester of pregnancy, cytotrophoblasts (CTBs) differentiate into extravillous
trophoblasts (EVTs). EVTs migrate from villus to decidua, invade maternal spiral arteries …

[HTML][HTML] 缺氧/复氧经DNA 甲基转移酶途径减弱人绒毛外滋养细胞的迁移和侵袭

胡司晨, 兰曦, 丁裕斌, 李方方, 陈恩祥, 付利娟 - 2023 - aammt.tmmu.edu.cn
目的探讨缺氧/复氧(hypoxia/reoxygenation, H/R) 对人绒毛外滋养细胞(extravillous
trophoblast, EVT) 侵袭能力的调控机制. 方法体外培养EVT 永生化细胞系HTR-8/SVneo …