Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

In studying the evolution of organic chemistry and grasping its essence, one comes quickly
to the conclusion that no other type of reaction plays as large a role in shaping this domain …

Taxol (a brand name for paclitaxel) is widely regarded as among the most famed natural
isolates ever discovered, and has been the subject of innumerable studies in both basic and …

Plant cell culture systems were initially explored for use in commercial synthesis of several
high‐value secondary metabolites, allowing for sustainable production that was not limited …

Paclitaxel, a tetracyclic diterpenoid compounds, was firstly isolated from the bark of the
Pacific yew trees. Currently, as a low toxicity, high efficiency, and broad-spectrum natural …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Natural products containing eight-membered carbocycles constitute a class of structurally
intriguing and biologically important molecules such as the famous diterpenes taxol and …

Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …

Wenn man die Entwicklung der organischen Chemie betrachtet, kommt man schnell zu dem
Schluss, dass kein Reaktionstyp dieses Gebiet in vergleichbarer Weise geprägt hat wie die …