Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies

N Zhang, J Nao, X Dong - Journal of Agricultural and Food …, 2023 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that
occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and …

USP25 ameliorates pathological cardiac hypertrophy by stabilizing SERCA2a in cardiomyocytes

B Ye, H Zhou, Y Chen, W Luo, W Lin, Y Zhao… - Circulation …, 2023 - Am Heart Assoc
Background: Pathological cardiac hypertrophy can lead to heart failure and is one of the
leading causes of death globally. Understanding the molecular mechanism of pathological …

[HTML][HTML] Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway

L She, L Xiong, L Li, J Zhang, J Sun, H Wu… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) has become a major public health problem affecting the elderly
population, and there is currently no effective treatment. Although the pathogenesis of AD is …

Targeted mitochondrial epigenetics: A new direction in alzheimer's disease treatment

Y Song, XY Zhu, XM Zhang, H Xiong - International Journal of Molecular …, 2022 - mdpi.com
Mitochondrial epigenetic alterations are closely related to Alzheimer's disease (AD), which is
described in this review. Reports of the alteration of mitochondrial DNA (mtDNA) methylation …

Salvianolic acid B ameliorates retinal deficits in an early-stage alzheimer's disease mouse model through downregulating bace1 and Aβ Generation

M Wang, S Zhang, X Liu, P Wang, Y Zhu… - Acta Pharmacologica …, 2023 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease with subtle onset, early diagnosis
remains challenging. Accumulating evidence suggests that the emergence of retinal …

USP25 ameliorates diabetic nephropathy by inhibiting TRAF6-mediated inflammatory responses

B Liu, X Miao, J Shen, L Lou, K Chen, F Mei… - International …, 2023 - Elsevier
Diabetic kidney disease (DKD) is a common diabetic vascular complication affecting nearly
40% of patients with diabetes. The lack of efficacious therapy for DKD necessitates the in …

USP25 inhibits neuroinflammatory responses after cerebral ischemic stroke by deubiquitinating TAB2

Z Li, B Liu, KL Lambertsen, BH Clausen… - Advanced …, 2023 - Wiley Online Library
Cerebral ischemic stroke is a leading cause of morbidity and mortality globally. However, the
mechanisms underlying ischemic stroke injury remain poorly understood. Here, it is found …

Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles

L Zhou, B Qin, DM Yassine, M Luo, X Liu… - Biochemical …, 2023 - Elsevier
Deubiquitination is the reverse process of ubiquitination, an important protein post-
translational modification. Deubiquitination is assisted by deubiquitinating enzymes (DUBs) …

The deacetylase SIRT6 reduces amyloid pathology and supports cognition in mice by reducing the stability of APP in neurons

R Cheng, N Bai, S Liu, X Zhao, B Jiang, W Guo… - Science …, 2024 - science.org
Alzheimer's disease (AD) is an aging-related neurodegenerative disorder that results in
progressively impaired memory and is often associated with amyloid plaques. Previous …

Targeting USP11 regulation by a novel lithium-organic coordination compound improves neuropathologies and cognitive functions in Alzheimer transgenic mice

Y Guo, C Cai, B Zhang, B Tan, Q Tang, Z Lei… - EMBO Molecular …, 2024 - embopress.org
Abstract Alzheimer's Disease (AD), as the most common neurodegenerative disease
worldwide, severely impairs patients' cognitive functions. Although its exact etiology remains …