MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …

Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …

Hepatitis C virus (HCV) infection represents the major cause of chronic liver disease,
leading to a wide range of hepatic diseases, including cirrhosis and hepatocellular …

Efficient hepatitis C virus (HCV) RNA accumulation is dependent upon interactions with the
human liver-specific microRNA, miR-122. MiR-122 has at least three roles in the HCV life …

Abstract microRNAs (miRNAs) are small, non-coding RNA molecules that play crucial
regulatory roles in numerous cellular processes. Recent investigations have highlighted the …

RNA molecules have emerged as promising clinical therapeutics due to their ability to
target" undruggable" proteins or molecules with high precision and minimal side effects …

Nowadays, infectious diseases of bacterial and viral origins represent a serious medical
problem worldwide. In fact, the development of antibiotic resistance is responsible for the …

Despite the advancement in antiviral therapy, Hepatitis C remains a global health challenge
and one of the leading causes of hepatitis related deaths worldwide. Hepatitis C virus, the …

RNA therapy is one of the new treatments using small RNA molecules to target and regulate
gene expression. It involves the application of synthetic or modified RNA molecules to inhibit …

Fibrosis can occur in many organs, and severe cases leading to organ failure and death. No
specific treatment for fibrosis so far. In recent years, microRNA-34a (miR-34a) has been …