With increasing life expectations, more and more patients suffer from fractures either
induced by intensive sports or other bone-related diseases. The balance between …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and
play important roles during bone development and fracture healing by supplying oxygen …

Background Mesenchymal stem cell (MSC)-based tissue engineering plays a major role in
regenerative medicine. However, the efficiency of MSC transplantation and survival of …

Strategies to optimize clinical genetic diagnostic pathways by combining both targeted and
next-generation sequencing are discussed. In addition to improved genetic counseling …

The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …

A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is
indispensable for the maintenance and remodeling of the adult skeleton. However, the cell …

The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly
regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and …

Current protocols for the differentiation of human pluripotent stem cells (hPSCs) into
chondrocytes do not allow for the expansion of intermediate progenitors so as to …