The pathological mechanisms underlying pulmonary hypertension (PH), as well as its
treatment strategy, are crucial issues in this field. This review aimed to summarize the …

Pulmonary arterial hypertension (PAH) in humans manifests as a chronic process. However,
PAH induced by high-dose monocrotaline (MCT) in animals occurs as a subacute process …

Background A pulmonary hypertensive crisis (PHC) can be a life-threatening condition. We
established a PHC model by exposing rats with monocrotaline (MCT)-induced pulmonary …

Objective This study investigated the interaction between COX-2, NO and ROS after
ischemia/reperfusion events in the kidney and vascular beds. Materials and methods Kidney …

This study aimed to investigate the therapeutic effects of aspirin (ASA) and its potential
mechanisms of action in monocrotaline (MCT)-induced pulmonary arterial hypertension …

Aims Pulmonary hypertension (PH) is characterized by progressive increases in pulmonary
vascular resistance (PVR). Thrombotic lesions are common pathological findings. The …

Purpose Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as
well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of …

Background Pulmonary arterial hypertension is a progressive angio-proliferative disease
associated with high morbidity and mortality rates. Although the histopathology of pulmonary …

ABSTRACT Objective: Endothelium-dependent (ED) and endothelium-independent (EI) flow-
mediated vasodilatation (FMD) have been used as measures of systemic arterial …

Hipertensão pulmonar (HP) é caracterizada por pressão arterial pulmonar (PAP) elevada e
hipertrofia ventricular direita (HVD). Devido à heterogeneidade dessa doença e seu caráter …