Chronic wounds remain a substantial source of morbidity worldwide. An emergent approach
that may be well‐suited to induce the complex, multicellular processes such as …

Skin cancer is one of the most prevalent cancers in the Caucasian population. In the United
States, it is estimated that at least one in five people will develop skin cancer in their lifetime …

Surgical flaps are rudimentary tools in reconstructive surgery, especially following extensive
solid tumour resections. They cover skin and soft tissue defects but are prone to ischaemia …

Abstract Hypoxia-Inducible Factor-1α (HIF-1α) has presented a new direction for ischemic
preconditioning of surgical flaps to promote their survival. In a previous study, we …

Surgical flaps are basic tools in reconstructive surgery. Their use may be limited by ischemia
and necrosis. Few therapies address or prevent them. Genetic therapy could improve flap …

Wound therapies involving gene delivery to the skin have significant potential due to the
advantage and ease of local treatment. However, choosing the appropriate vector to enable …

Wounds pose significant challenges to public health, primarily due to the loss of the
mechanical integrity and barrier function of the skin and impaired angiogenesis, causing …

The clinical application of random flaps in wound repair has been a topic of discussion.
Random flaps are prone to necrosis due to the lack of well-defined vascular blood supply …

Background Hypoxia-inducible factor-1α (HIF-1α), regulated by prolyl hydroxylase, plays a
central role in tissue adaptation to ischemia. This study investigates the impact of HIF-1α on …