Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

For more than 50 years, psychologists, gerontologists, and, more recently, neuroscientists
have considered the possibility of successful aging. How to define successful aging remains …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Abstract The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Consortium is a collaborative network of researchers working together on a range of large …

Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …

To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …

We identify common genetic variants associated with cognitive performance using a two-
stage approach, which we call the proxy-phenotype method. First, we conduct a genome …

General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this …

International evidence suggests that green space has beneficial effects on general and
mental health but little is known about how lifetime exposure to green space influences …

Background Apolipoprotein E (APOE) ε4 is the single most important genetic risk factor for
cognitive impairment and Alzheimer disease (AD), while lifestyle factors such as smoking …