Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology
Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …
physical object (eg, planes and human organs), predict the behavior of the object, and …
Optimal control theory for personalized therapeutic regimens in oncology: Background, history, challenges, and opportunities
Optimal control theory is branch of mathematics that aims to optimize a solution to a
dynamical system. While the concept of using optimal control theory to improve treatment …
dynamical system. While the concept of using optimal control theory to improve treatment …
Determining the thermal characteristics of breast cancer based on high-resolution infrared imaging, 3D breast scans, and magnetic resonance imaging
A Lozano III, JC Hayes, LM Compton, J Azarnoosh… - Scientific reports, 2020 - nature.com
For over the three decades, various researchers have aimed to construct a thermal (or
bioheat) model of breast cancer, but these models have mostly lacked clinical data. The …
bioheat) model of breast cancer, but these models have mostly lacked clinical data. The …
[HTML][HTML] Fluid mechanics in circulating tumour cells: role in metastasis and treatment strategies
Cancer patients have a shorter life expectancy because of metastasis, which is the dynamic
chain of events that leads to the spread of tumour cells to distant places inside the body …
chain of events that leads to the spread of tumour cells to distant places inside the body …
Biologically-based mathematical modeling of tumor vasculature and angiogenesis via time-resolved imaging data
Simple Summary The recruitment of new vasculature via angiogenesis is a critical
component of tumor development, which fundamentally influences tumor growth and …
component of tumor development, which fundamentally influences tumor growth and …
Optimal control of cytotoxic and antiangiogenic therapies on prostate cancer growth
Prostate cancer can be lethal in advanced stages, for which chemotherapy may become the
only viable therapeutic option. While there is no clear clinical management strategy fitting all …
only viable therapeutic option. While there is no clear clinical management strategy fitting all …
Current status in spatiotemporal analysis of contrast‐based perfusion MRI
In perfusion MRI, image voxels form a spatially organized network of systems, all
exchanging indicator with their immediate neighbors. Yet the current paradigm for perfusion …
exchanging indicator with their immediate neighbors. Yet the current paradigm for perfusion …
Theranostic digital twins for personalized radiopharmaceutical therapies: Reimagining theranostics via computational nuclear oncology
This work emphasizes that patient data, including images, are not operable (clinically), but
that digital twins are. Based on the former, the latter can be created. Subsequently, virtual …
that digital twins are. Based on the former, the latter can be created. Subsequently, virtual …
Towards patient-specific optimization of neoadjuvant treatment protocols for breast cancer based on image-guided fluid dynamics
Objective: This study establishes a fluid dynamics model personalized with patient-specific
imaging data to optimize neoadjuvant therapy (ie, doxorubicin) protocols for breast cancers …
imaging data to optimize neoadjuvant therapy (ie, doxorubicin) protocols for breast cancers …
Modeling and simulation of vascular tumors embedded in evolving capillary networks
In this work, we present a coupled 3D–1D model of solid tumor growth within a dynamically
changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the …
changing vascular network to facilitate realistic simulations of angiogenesis. Additionally, the …