The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …

Chromosome conformation capture approaches have shown that interphase chromatin is
partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological …

Organisms represent a complex arrangement of anatomical structures and individuated
parts that must maintain functional associations through development. This integration of …

The evolutionarily conserved cohesin complex was originally described for its role in
regulating sister-chromatid cohesion during mitosis and meiosis. Cohesin and its regulatory …

Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include
cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome …

The closely linked human protocadherin (Pcdh) α, β, and γ gene clusters encode 53 distinct
protein isoforms, which are expressed in a combinatorial manner to generate enormous …

Cornelia de Lange syndrome (CdLS; MIM# 122470, 300590, 610759, 614701, 300882) is a
rare and clinically variable disorder that affects multiple organs. It is characterized by …