Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
Dietary regulation in health and disease
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …
in molecular medicine and clinical trials have demonstrated that adequate nutrition …
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects
E Dierge, E Debock, C Guilbaud, C Corbet, E Mignolet… - Cell metabolism, 2021 - cell.com
Tumor acidosis promotes disease progression through a stimulation of fatty acid (FA)
metabolism in cancer cells. Instead of blocking the use of FAs by acidic cancer cells, we …
metabolism in cancer cells. Instead of blocking the use of FAs by acidic cancer cells, we …
Metabolic and signaling roles of ketone bodies in health and disease
P Puchalska, PA Crawford - Annual review of nutrition, 2021 - annualreviews.org
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …
[HTML][HTML] Ketogenic diet in the treatment of cancer–where do we stand?
DD Weber, S Aminzadeh-Gohari, J Tulipan… - Molecular …, 2020 - Elsevier
Background Cancer is one of the greatest public health challenges worldwide, and we still
lack complementary approaches to significantly enhance the efficacy of standard anticancer …
lack complementary approaches to significantly enhance the efficacy of standard anticancer …
Methionine metabolism in health and cancer: a nexus of diet and precision medicine
Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
Mitochondrial metabolism and cancer
Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
Fasting and cancer: molecular mechanisms and clinical application
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …
metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) …
Metabolic reprogramming and epigenetic modifications on the path to cancer
L Sun, H Zhang, P Gao - Protein & cell, 2022 - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
regulate each other, are among the well-known cancer hallmarks. Recent evidence …