The genetically informed neurobiology of addiction (GINA) model
Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
neurobiological theory proposes that substance-induced changes in neural circuitry promote …
The molecular pathology of schizophrenia: An overview of existing knowledge and new directions for future research
T Nakamura, A Takata - Molecular Psychiatry, 2023 - nature.com
Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease
Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …
that occur in specific cell types have not been fully characterized. Here, we profile single …
[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
Upper cortical layer–driven network impairment in schizophrenia
Schizophrenia is one of the most widespread and complex mental disorders. To
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing …
Neuronal ambient RNA contamination causes misinterpreted and masked cell types in brain single-nuclei datasets
E Caglayan, Y Liu, G Konopka - Neuron, 2022 - cell.com
Ambient RNA contamination in single-cell and single-nuclei RNA sequencing (snRNA-seq)
is a significant problem, but its consequences are poorly understood. Here, we show that …
is a significant problem, but its consequences are poorly understood. Here, we show that …
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
[HTML][HTML] Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
Neuroimaging and multiomics reveal cross-scale circuit abnormalities in schizophrenia
Schizophrenia (SCZ) is a highly heterogeneous disorder with diverse clinical manifestations
and macro-and microscale biological variations, usually observed at dissociable levels …
and macro-and microscale biological variations, usually observed at dissociable levels …
Multi-omic profiling of the developing human cerebral cortex at the single-cell level
The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …
expression throughout development that is mediated, in part, by the spatiotemporal activity …