Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021
WHO CNS5 classification has further stressed the importance of molecular signatures in …

Simple Summary Due to the lack of selectivity and the severe side-effects, cytostatics are the
drugs of the present but not of the future and consequently new anticancer strategies must …

Targeting the redox balance of malignant cells via the delivery of high oxidative stress
unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a …

Importance Disulfiram has demonstrated broad antitumoral effect in several preclinical
studies. One of the proposed indications is for the treatment of glioblastoma. Objective To …

Background The dismal prognosis of glioblastoma (GBM) may be related to the ability of
GBM cells to develop mechanisms of treatment resistance. We designed a protocol called …

Glioblastoma (GBM) is the most common primary central nervous system tumor in adults. It is
a highly invasive disease, making it difficult to achieve a complete surgical resection …

Cancer metastasis and treatment resistance are the main causes of treatment failure and
cancer-related deaths. Their underlying mechanisms remain to be fully elucidated and have …

Simple Summary Glioblastoma is a devastating malignancy that has continued to prove
resistant to a variety of therapeutics. No new systemic therapy has been approved for use …

Background A major barrier to effective treatment of glioblastoma (GBM) is the large
intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials …

Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in
contrast to the known hurdles of developing new molecular entities, the approach of …