Ototoxicity of ototopical drops—an update

DS Haynes, J Rutka, M Hawke, PS Roland - Otolaryngologic Clinics of …, 2007 - Elsevier
Various topical preparations are widely used for treating external otitis, acute otitis media
with perforation, post-tympanostomy tube otorrhea, and chronic suppurative otitis media …

Controlled multicenter study on chronic suppurative otitis media treated with topical applications of ciprofloxacin 0.2% solution in single-dose containers or …

N Miró… - Otolaryngology–Head and …, 2000 - journals.sagepub.com
Otic drops of either ciprofloxacin 0.2% solution (CIP) or a combination of polymyxin B,
neomycin, and hydrocortisone suspension (PNH) were administered for 6 to 12 days to …

Topical ciprofloxacin/dexamethasone is superior to ciprofloxacin alone in pediatric patients with acute otitis media and otorrhea through tympanostomy tubes

PS Roland, JB Anon, RD Moe, PJ Conroy… - The …, 2003 - Wiley Online Library
Objective To determine whether topical administration of a corticosteroid improves
resolution of acute tympanostomy tube otorrhea when combined with topical antibiotic …

Topical ciprofloxacin for otorrhea after tympanostomy tube placement

RW Force, MC Hart, SA Plummer… - … –Head & Neck …, 1995 - jamanetwork.com
Objective: To evaluate the efficacy, systemic absorption, and safety of ototopically
administered ciprofloxacin in children with otorrhea associated with tympanostomy tube …

Ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension for the topical treatment of ear infections: a review of the literature

GM Wall, DW Stroman, PS Roland… - The Pediatric infectious …, 2009 - journals.lww.com
The objective of this article is to review the literature related to ciprofloxacin 0.3% and
dexamethasone 0.1% sterile otic suspension. A systematic literature search utilizing Medline …

Clinical use of fluoroquinolones in children

AA Alghasham, MC Nahata - Annals of pharmacotherapy, 2000 - journals.sagepub.com
OBJECTIVE: To review the pharmacokinetics, efficacy, and safety of fluoroquinolones in
children. DATA SOURCES: A MEDLINE search (January 1966–March 1998) was conducted …

Efficacy and safety of ciprofloxacin plus fluocinolone acetonide among patients with acute otitis externa: A randomized clinical trial

L Chu, AM Acosta, H Aazami, P Dennis… - JAMA Network …, 2022 - jamanetwork.com
Importance Ciprofloxacin, 0.3%, plus fluocinolone acetonide, 0.025%, otic solution seems to
be efficacious and safe in treating acute otitis externa (AOE) compared with ciprofloxacin …

Efficacy and safety of topical ciprofloxacin/dexamethasone versus neomycin/polymyxin B/hydrocortisone for otitis externa

PS Roland, FD Pien, CC Schultz… - … medical research and …, 2004 - Taylor & Francis
Objectives: To compare the efficacy and safety of ciprofloxacin 0.3%/dexamethasone
0.1%(CIP/DEX) otic suspension with that of neomycin 0.35%/polymyxin B 10 000 …

Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects

PS Roland, L Rybak, M Hannley, G Matz… - … –Head and Neck …, 2004 - Wiley Online Library
OBJECTIVE The objective of this study was to systematically review the literature on animal
ototoxicity from ototopical medications. A secondary objective was to assess the relevance …

Susceptibility of microorganisms isolated from chronic suppurative otitis media to ciprofloxacin

A Altuntas, A Aslan, N Eren, A Unal, Y Nalca - European archives of oto …, 1996 - Springer
In order to evaluate the susceptibility of the microorganisms isolated from chronic
suppurative otitis media to ciprofloxacin, cultures of specimens from 127 patients with …