FGF/FGFR signaling in health and disease

Y Xie, N Su, J Yang, Q Tan, S Huang, M Jin… - Signal transduction and …, 2020 - nature.com
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

K Lee, EA Silva, DJ Mooney - Journal of the Royal …, 2011 - royalsocietypublishing.org
The identification and production of recombinant morphogens and growth factors that play
key roles in tissue regeneration have generated much enthusiasm and numerous clinical …

The FGF family: biology, pathophysiology and therapy

A Beenken, M Mohammadi - Nature reviews Drug discovery, 2009 - nature.com
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …

Hydrogels for protein delivery in tissue engineering

R Censi, P Di Martino, T Vermonden… - Journal of Controlled …, 2012 - Elsevier
Tissue defects caused by diseases or trauma present enormous challenges in regenerative
medicine. Recently, a better understanding of the biological processes underlying tissue …

[HTML][HTML] Fibroblast growth factor (FGF) signaling in development and skeletal diseases

CM Teven, EM Farina, J Rivas, RR Reid - Genes & diseases, 2014 - Elsevier
Fibroblast growth factors (FGF) and their receptors serve many functions in both the
developing and adult organism. Humans contain 18 FGF ligands and four FGF receptors …

Synthetic mRNA encoding VEGF-A in patients undergoing coronary artery bypass grafting: design of a phase 2a clinical trial

V Anttila, A Saraste, J Knuuti, P Jaakkola… - … therapy Methods & …, 2020 - cell.com
Therapeutic angiogenesis may improve outcomes in patients with coronary artery disease
undergoing surgical revascularization. Angiogenic factors may promote blood vessel growth …

Angiogenesis: where do we stand now?

M Simons - Circulation, 2005 - Am Heart Assoc
The role of preexisting collateral channels in the heart is far less well established. Early
studies failed to show the existence of coronary-to-coronary artery connection in normal …

Incorporation of heparin into biomaterials

SE Sakiyama-Elbert - Acta biomaterialia, 2014 - Elsevier
This review provides an overview of the incorporation of heparin into biomaterials with a
focus on drug delivery and the use of heparin-based biomaterials for self-assembly of …

Design principles for therapeutic angiogenic materials

PS Briquez, LE Clegg, MM Martino… - Nature Reviews …, 2016 - nature.com
Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …

Therapeutic angiogenesis in cardiovascular disease

M Simons, JA Ware - Nature reviews Drug discovery, 2003 - nature.com
Despite considerable progress in the management of ischaemic cardiovascular disease
during the past three decades, there remains a significant population of patients who are not …