Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics

A Ajoolabady, S Wang, G Kroemer… - Pharmacology & …, 2021 - Elsevier
Stroke constitutes the second leading cause of death and a major cause of disability
worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) …

Macroautophagy and aging: The impact of cellular recycling on health and longevity

JL Nieto-Torres, M Hansen - Molecular aspects of medicine, 2021 - Elsevier
Aging is associated with many deleterious changes at the cellular level, including the
accumulation of potentially toxic components that can have devastating effects on health. A …

Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies

MF Almeida, KLG Farizatto, RS Almeida… - Ageing Research …, 2024 - Elsevier
Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition,
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …

Physical activity vs. redox balance in the brain: brain health, aging and diseases

P Sutkowy, A Woźniak, C Mila-Kierzenkowska… - Antioxidants, 2021 - mdpi.com
It has been proven that physical exercise improves cognitive function and memory, has an
analgesic and antidepressant effect, and delays the aging of the brain and the development …

Synucleinopathy-associated pathogenesis in Parkinson's disease and the potential for brain-derived neurotrophic factor

KM Miller, NM Mercado, CE Sortwell - NPJ Parkinson's disease, 2021 - nature.com
The lack of disease-modifying treatments for Parkinson's disease (PD) is in part due to an
incomplete understanding of the disease's etiology. Alpha-synuclein (α-syn) has become a …

Effects of physical exercise on autophagy and apoptosis in aged brain: Human and animal studies

DZ Andreotti, JN Silva, AM Matumoto… - Frontiers in …, 2020 - frontiersin.org
The aging process is characterized by a series of molecular and cellular changes over the
years that could culminate in the deterioration of physiological parameters important to …

Exercise-induced autophagy ameliorates motor symptoms progressivity in Parkinson's disease through alpha-synuclein degradation: a review

H Goenawan, S Kiasati, N Sylviana… - Neuropsychiatric …, 2023 - Taylor & Francis
This study reviews the molecular mechanism of exercise-induced autophagy/mitophagy and
its possible mechanism in delaying motor symptoms progressivity in Parkinson's disease …

Brain ageing and neurodegenerative disease: The role of cellular waste management

S Daniele, C Giacomelli, C Martini - Biochemical pharmacology, 2018 - Elsevier
Ageing is defined as a time-dependent functional decline that occurs in most of live
organisms. Brain modification during the ageing process has been considered to …

The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review

AFF Ferreira, KH Binda, CC Real - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Parkinson's disease (PD) is a progressive disabling brain disorder. Physical exercise has
been shown to alleviate the symptoms of PD and, consequently, improve patient quality of …

[HTML][HTML] Compromised autophagy and mitophagy in brain ageing and Alzheimer's diseases

D Caponio, K Veverová, S Zhang, L Shi, G Wong… - Aging Brain, 2022 - Elsevier
Alzheimer's disease (AD) is one of the most persistent and devastating neurodegenerative
disorders of old age, and is characterized clinically by an insidious onset and a gradual …