Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to
develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to …

A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid
synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious …

In 1967, it was reported that experimental inoculation of serum from a surgeon (GB) with
acute hepatitis into tamarins resulted in hepatitis. In 1995, two new members of the family …

Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …

Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development
of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world …

Hepatitis C virus (HCV) infection is a global health concern affecting an estimated 3% of the
world's population. Recently, cell culture systems have been established, allowing …