Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
A joint NCBI and EMBL-EBI transcript set for clinical genomics and research
J Morales, S Pujar, JE Loveland, A Astashyn, R Bennett… - Nature, 2022 - nature.com
Comprehensive genome annotation is essential to understand the impact of clinically
relevant variants. However, the absence of a standard for clinical reporting and browser …
relevant variants. However, the absence of a standard for clinical reporting and browser …
Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
SD Kasowitz, J Ma, SJ Anderson, NA Leu, Y Xu… - PLoS …, 2018 - journals.plos.org
The N 6-methyladenosine (m6A) modification is the most prevalent internal RNA
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …
modification in eukaryotes. The majority of m6A sites are found in the last exon and 3'UTRs …
Neoantigens: promising targets for cancer therapy
Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
U1 snRNP regulates cancer cell migration and invasion in vitro
Stimulated cells and cancer cells have widespread shortening of mRNA 3'-untranslated
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …
Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
NJ Proudfoot - Science, 2016 - science.org
BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
Multiplexed single-cell characterization of alternative polyadenylation regulators
Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …
Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
A deep neural network for predicting and engineering alternative polyadenylation
Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …