Membranes: a meeting point for lipids, proteins and therapies

PV Escribá, JM González‐Ros, FM Goñi… - Journal of cellular …, 2008 - Wiley Online Library
• Introduction• Membrane lipid composition• Membrane lipid structure• Membrane lipid
organization‐Why so many different lipids?‐Lipid mixing and demixing‐Lateral pressure …

Biophysical properties of lipids and dynamic membranes

PA Janmey, PKJ Kinnunen - Trends in cell biology, 2006 - cell.com
The lipid bilayer is a 3D assembly with a rich variety of physical features that modulate cell
signaling and protein function. Lateral and transverse forces within the membrane are …

Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

L Schnaider, S Brahmachari, NW Schmidt… - Nature …, 2017 - nature.com
Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

On the selectivity and efficacy of defense peptides with respect to cancer cells

F Harris, SR Dennison, J Singh… - Medicinal research …, 2013 - Wiley Online Library
Here, we review potential determinants of the anticancer efficacy of innate immune peptides
(ACPs) for cancer cells. These determinants include membrane‐based factors, such as …

Amyloid-based nanosensors and nanodevices

CAE Hauser, S Maurer-Stroh, IC Martins - Chemical Society Reviews, 2014 - pubs.rsc.org
Self-assembling amyloid-like peptides and proteins give rise to promising biomaterials with
potential applications in many fields. Amyloid structures are formed by the process of …

The role of lipid–protein interactions in amyloid-type protein fibril formation

GP Gorbenko, PKJ Kinnunen - Chemistry and physics of lipids, 2006 - Elsevier
Structural transition of polypeptide chains into the β-sheet state followed by amyloid fibril
formation is the key characteristic of a number of the so-called conformational diseases. The …

Amyloid peptides and proteins in review

RS Harrison, PC Sharpe, Y Singh, DP Fairlie - Reviews of physiology …, 2007 - Springer
Amyloids are filamentous protein deposits ranging in size from nanometres to microns and
composed of aggregated peptide β-sheets formed from parallel or anti-parallel alignments of …

Molecular and cellular aspects of protein misfolding and disease

E Herczenik, MFBG Gebbink - The FASEB Journal, 2008 - Wiley Online Library
Proteins are essential elements for life. They are building blocks of all organisms and the
operators of cellular functions. Humans produce a repertoire of at least 30,000 different …

Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity

M Stefani - The FEBS journal, 2010 - Wiley Online Library
A great deal must still be learnt on the structural features of amyloid assemblies, particularly
prefibrillar aggregates, and the relationship of the latter with amyloid cytotoxicity. Presently, it …

How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?

BF Shaw, JS Valentine - Trends in biochemical sciences, 2007 - cell.com
More than 100 different mutations in the gene encoding copper-zinc superoxide dismutase
(SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS)–a fatal …