Lower respiratory tract infections are associated with high morbidity and mortality and
significant clinical harm. Due to the limited ability of traditional pathogen detection methods …

Abstract The Consortium on Adventitious Agent Contamination in Biomanufacturing
(CAACB) collected historical data from 20 biopharmaceutical industry members on their …

High-throughput sequencing (HTS) is capable of broad virus detection encompassing both
known and unknown adventitious viruses in a variety of sample matrices. We describe the …

It is important to increase manufacturing speed to make medicines more widely available.
One bottleneck for CHO‐based drug substance release is the in vitro viral (IVV) cell‐based …

Background Unbiased deep sequencing offers the potential for improved adventitious virus
screening in vaccines and biotherapeutics. Successful implementation of such assays will …

Contamination is commonly used as a term for the presence of undesired microorganisms,
unwanted mammalian cells, and various biochemical or chemicals present in the cell culture …

Pulmonary actinomycosis (PA) is an uncommon pulmonary infectious disease often is
misdiagnosed. Microbiological next-generation sequencing (mNGS) is a high sensitive and …

Next-generation sequencing (NGS), also known as high-throughput sequencing (HTS), is a
commonly used term to represent a set of DNA sequencing technologies that have been in …

The genetic stability of cell lines is a critical analytical attribute required to demonstrate the
quality of cells over time. During cell passage, mutations can arise in the genomic DNA …

We have designed and implemented a software system, named PhyloID™, that can be used
to detect putative adventitious agents in biological samples characterized by next …