The role of vascular endothelial growth factor in tendon healing

X Liu, B Zhu, Y Li, X Liu, S Guo, C Wang, S Li… - Frontiers in …, 2021 - frontiersin.org
Angiogenesis is crucial to facilitate tendon healing, such as delivering oxygen and nutrients,
removing waste products, and controlling immune responses. Vascular endothelial growth …

Non-viral delivery of gene therapy to the tendon

J Jin, QQ Yang, YL Zhou - Polymers, 2022 - mdpi.com
The tendon, as a compact connective tissue, is difficult to treat after an acute laceration or
chronic degeneration. Gene-based therapy is a highly efficient strategy for diverse diseases …

Robustness of digital PCR and real-time PCR in transgene detection for gene-doping control

T Tozaki, A Ohnuma, S Iwai, M Kikuchi… - Analytical …, 2021 - ACS Publications
Gene doping is banned in human sports, horseracing, and equestrian sports. One possible
form of gene doping is to administer exogenous genes, called transgenes. Several …

Identification of processed pseudogenes in the genome of Thoroughbred horses: Possibility of gene‐doping detection considering the presence of pseudogenes

T Tozaki, A Ohnuma, M Kikuchi, T Ishige… - Animal …, 2022 - Wiley Online Library
Processed pseudogenes, also known as retrocopy genes, are copies of messenger RNAs
that have been reverse transcribed into DNA and inserted into the genome. In this study, we …

Viable tendon neotissue from adult adipose-derived multipotent stromal cells

T Taguchi, M Lopez, C Takawira - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Background: Tendon healing is frequently prolonged, unpredictable, and results in poor
tissue quality. Neotissue formed by adult multipotent stromal cells has the potential to guide …

Administration and detection of gene therapy in horses: A systematic review

J Haughan, KF Ortved… - Drug testing and analysis, 2023 - Wiley Online Library
Gene therapy uses genetic modification of cells to produce a therapeutic effect. Defective or
missing genes can be repaired or replaced, or gene expression can be modified using a …

Gene doping in horse racing and equine sports: Current landscape and future perspectives

M Puchalska… - Equine Veterinary …, 2024 - Wiley Online Library
Gene doping, the use of gene therapy or genetic manipulation to enhance athletic
performance, has emerged as a potential threat to the integrity and welfare of equine sports …

A method for detecting gene doping in horse sports without DNA extraction

R Furukawa, T Tozaki, M Kikuchi… - Drug Testing and …, 2024 - Wiley Online Library
Gene doping is prohibited in horse sports and can involve the administration of exogenous
genes, called transgenes, to postnatal animals. Quantitative polymerase chain reaction …

Genetic therapy in veterinary medicine

EY Zakirova, AG Malanyeva, CS Rutland… - BioNanoScience, 2022 - Springer
Gene therapy focuses on the genetic modification of cells, to produce a therapeutic effect or
for the treatment of disease, by repairing or reconstructing defective genetic material. The …

LncRNA AC108925 promotes osteoblast differentiation of tendon-derived stem cells by targeting miR-146a-3p

J Liu, Z Zhao, Z Deng, X Chen, W Li - Pathology-Research and Practice, 2023 - Elsevier
It has been reported that tendon-derived stem cells (TDSCs) conduce to the ostosis in
tendon diseases, and the molecular mechanism needs to be discussed. To investigate the …