Cyanobacterial blooms occur when algal densities exceed baseline population
concentrations. Cyanobacteria can produce a large number of secondary metabolites …

Background: Despite significant advancement in oncology research, cancer still poses one
of the leading causes of mortality worldwide. The increased incidences of cancer may be …

Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

The thyroid hormone (TH) system is involved in several important physiological processes,
including regulation of energy metabolism, growth and differentiation, development and …

The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated
in iodide uptake into thyroid follicular cells. It plays a crucial role in iodine metabolism and …

Abstract The US EPA's Endocrine Disruptor Screening Program aims to use high-throughput
assays and computational toxicology models to screen and prioritize chemicals that may …

A small library of dihydropyrimidin-2-ones (DHPMs) was synthesized and evaluated for their
potency to block iodide entrapment in rat thyroid cells. Synthesis was achieved using the …

The standard assay for sodium iodide symporter (NIS) function is based on the
measurement of radioiodide uptake (125I) in NIS-expressing cells. However, cost and safety …

Nicofluprole is a novel insecticide of the phenylpyrazole class conferring selective
antagonistic activity on insect GABA receptors. After repeated daily dietary administration to …

Nature is a prolific source of organic products with diverse scaffolds and biological activities.
The process of natural product discovery has gradually become more challenging, and …