Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

Activated platelets play a role in the pathogenesis of coronary heart disease (CHD).
Following activation, platelets change shape, aggregate, and release several bioactive …

Objectives: We investigated the relation of high ex vivo platelet reactivity, rapid fibrin
generation, and high thrombin-induced clot strength to postdischarge ischemic events in …

To assess platelet function profiles in diabetic and nondiabetic patients on aspirin and
clopidogrel therapy, two patient populations were included to investigate the 1) acute effects …

Dyslipidemia is associated with a prothrombotic phenotype; however, the mechanisms
responsible for enhanced platelet reactivity remain unclear. Proatherosclerotic lipid …

Objectives: This study sought to determine the prognostic implications of high platelet
reactivity (HPR) assessed in type 2 diabetes mellitus (T2DM) patients while in their steady …

BACKGROUND: Patients with acute coronary syndromes (ACS; unstable angina and non–
ST-segment elevation myocardial infarction) are at significant risk for death and myocardial …

Hyperglycemia has been linked to adverse outcomes after myocardial infarction. We
characterized the effect of selected concentrations of glucose or mannitol on platelet function …

Aggregometry is widely used to assess platelet function, but its use in identifying platelet
hyperreactivity is poorly defined. We studied platelet aggregation in 359 healthy individuals …

Objectives: We sought to determine the safety and efficacy of high-dose bolus (HDB)
tirofiban in high-risk patients undergoing percutaneous coronary intervention (PCI) …