Pulmonary arterial hypertension (PAH) is a devastating disease that is precipitated by
hypertrophic pulmonary vascular remodeling of distal arterioles to increase pulmonary artery …

In the past 10 years, there has been tremendous progress made in the field of gene therapy.
Effective treatments of Leber congenital amaurosis, hemophilia, and spinal muscular …

Emerging studies have reported the mechanosensitive Piezo1 (piezo type
mechanosensitive ion channel component 1) plays essential roles in regulating the vascular …

Pulmonary arterial hypertension (PAH) is a progressive and fatal lung disease of
multifactorial etiology. Most of the available drugs and FDA-approved therapies for treating …

Although postcapillary pulmonary hypertension (PH) is an important prognostic factor for
patients with heart failure (HF), its pathogenesis remains to be fully elucidated. To elucidate …

Pulmonary hypertension (PH) is an often-fatal vascular disease of unclear molecular origins.
The pulmonary vascular remodelling which occurs in PH is characterised by elevated …

SUMOylation of sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2a (SERCA2a) has
been shown to play a critical role in the abnormal Ca 2+ cycle of heart failure. Ginsenoside …

The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous
membranous network that fulfills multiple homeostatic functions. Among them, it …

Genetic modification therapy is a promising therapeutic strategy for many diseases of the
lung intractable to other treatments. Lung gene therapy has been the subject of numerous …

Introduction Inhaled gene therapy programs targeting diseases of the lung have seen
increasing interest in recent years, though as of yet no product has successfully entered the …