Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Siponimod is a selective sphingosine 1-phosphate receptor subtype 1 (S1P1) and 5 (S1P5)
modulator approved in the United States and the European Union as an oral treatment for …

Abstract Introduction Coronavirus disease 2019 (COVID-19) is strongly linked to
dysregulation of various molecular, cellular, and physiological processes that change …

Background Ozanimod, a high selective sphingosine 1 phosphate (S1P) receptor (S1PR)
1/5 modulator was approved by the Food and Drug Administration for the treatment of adult …

This study was designed to explore whether exosomal sphingosine 1‐phosphate (S1P) from
mesenchymal stem cells (MSCs) regulate the Treg/Th17 balance in aplastic anemia (AA) …

Sphingosine 1-phosphate (S1P) and S1P receptors (S1PR) regulate many cellular
processes, including lymphocyte migration and endothelial barrier function. As neutrophils …

Inflammation and resolution are dynamic processes comprised of inflammatory activation
and neutrophil influx, followed by mediator catabolism and efferocytosis. These critical …

Activation of microglia and/or astrocytes often releases proinflammatory molecules as critical
pathogenic mediators that can promote neuroinflammation and secondary brain damages in …

Disruption of the lung endothelial barrier is a hallmark of acute respiratory distress syndrome
(ARDS), for which no effective pharmacologic treatments exist. Prior work has demonstrated …

Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-
phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some …