Reactive oxygen species as a link between antioxidant pathways and autophagy

D Li, Z Ding, K Du, X Ye… - Oxidative Medicine and …, 2021 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive molecules that can oxidize proteins,
lipids, and DNA. Under physiological conditions, ROS are mainly generated in the …

Effects of puerarin on the prevention and treatment of cardiovascular diseases

YX Zhou, H Zhang, C Peng - Frontiers in Pharmacology, 2021 - frontiersin.org
Puerarin, an isoflavone glycoside derived from Pueraria lobata (Willd.) Ohwi, has been
identified as a pharmacologically active component with diverse benefits. A large number of …

Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression

YH Ko, SK Kim, SY Lee, CG Jang - Archives of pharmacal research, 2020 - Springer
Emotional disorders such as anxiety and depression are widespread psychological
diseases that affect up to 20% of the world's population. There are many approaches to the …

The role of autophagy in cardiovascular disease: Cross-interference of signaling pathways and underlying therapeutic targets

B Jiang, X Zhou, T Yang, L Wang, L Feng… - Frontiers in …, 2023 - frontiersin.org
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic proteins
and organelles, which realizes the metabolic needs of cells and the renewal of organelles …

Natural marine and terrestrial compounds as modulators of matrix metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's disease

L Ciccone, J Vandooren, S Nencetti, E Orlandini - Pharmaceuticals, 2021 - mdpi.com
Several studies have reported neuroprotective effects by natural products. A wide range of
natural compounds have been investigated, and some of these may play a beneficial role in …

Identification of Nutritional Ingredients and Medicinal Components of Pueraria lobata and Its Varieties Using UPLC-MS/MS-Based Metabolomics

X Shang, D Huang, Y Wang, L Xiao, R Ming, W Zeng… - Molecules, 2021 - mdpi.com
Pueraria lobata and its variety P. lobata var. thomsonii are both traditional Chinese
medicines that have high nutritional and medical value; whereas another variety, P. lobata …

Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials

Z Long, W Xiang, Q He, W Xiao, H Wei, H Li… - Frontiers in …, 2023 - frontiersin.org
Objective To evaluate safety and efficacy of dietary polyphenols in the treatment of
rheumatoid arthritis (RA). Methods CNKI, Pubmed, Cochrane library, Embase were …

A review on dietary flavonoids as modulators of the tumor microenvironment

N Duan, X Hu, R Zhou, Y Li, W Wu… - Molecular Nutrition & …, 2023 - Wiley Online Library
The tumor microenvironment (TME) is the local environment where malignant cells strive
and survive, composed of cancer cells and their surroundings, regulating essential tumor …

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

Q Wang, ZN Shen, SJ Zhang, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Neurological diseases impose a tremendous and increasing burden on global health, and
there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried …

Exploring the mechanism and experimental verification of puerarin in the treatment of endometrial carcinoma based on network pharmacology and bioinformatics …

Z Lin, X Sui, W Jiao, Y Wang, J Zhao - BMC Complementary Medicine and …, 2022 - Springer
Endometrial carcinoma is one of the two cancers with rising mortality and morbidity in recent
years. In the light of many controversies about its treatment, it is urgent to construct a new …