The prevalence of diabetes mellitus is on the rise, which demands the identification of novel
antidiabetic drugs. There is a need for safer and more effective alternatives because the …

Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat
type 2 diabetes mellitus (T2DM). They may be combined with other medications as an …

In our work, several 7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-phenylhydrazone
derivatives as α-glucosidase inhibitors (α-GIs) were synthesized and characterized by 1 H …

A series of new benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone hybrid analogs (Tz1-
Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study …

The aim of the present study is to design and synthesis of new pyrazole-triazolopyrimidine
hybrids as potent α-glucosidase inhibitors. The target compounds 4a-n were synthesized by …

A new azo dye ligand 2-[2'-(6-methoxybenzothiazolyl) azo]-4-ethoxyphenol (6-MBTAEP)
was prepared by reacting a diazonium chloride salt solution of 2-amino-6-methoxy …

The present manuscript describes the synthesis, α-amylase inhibition, in silico studies and in-
depth quantitative structure–activity relationship (QSAR) of a library of aroyl hydrazones …

This work aimed to synthesize safe antihyperglycemic derivatives bearing thiazolidinedione
fragment based on spectral data. The DFT theory discussed the frontier molecular orbitals …

Currently, there are several drugs used for the treatment of type 2 diabetes (T2D); however,
all of them have adverse effects. Benzothiazoles have a broad spectrum of biological …

Abstract We suggest a [3+ 2] annulation method that combines aromatic acid with acyl
hydrazide using p-TSA, resulting in the formation of highly substituted 1, 3, 4-oxadiazole …