Neuronal communication requires precise connectivity of neurite projections (axons and
dendrites). Developing neurites express cell-surface receptors that interpret extracellular …

Cell polarity mechanisms allow the formation of specialized membrane domains with unique
protein compositions, signalling properties, and functional characteristics. By analyzing the …

Polarity is the basis for the generation of cell diversity, as well as the organization,
morphogenesis, and functioning of tissues. Studies in Caenorhabditis elegans have …

The Wnt family contains conserved secretory proteins required for developmental patterning
and tissue homeostasis. However, how Wnt is targeted to the endoplasmic reticulum (ER) for …

The assembly of neuronal circuits involves the migrations of neurons from their place of birth
to their final location in the nervous system, as well as the coordinated growth and patterning …

The plasma membrane of excitable cells is highly structured and molecular scaffolds recruit
proteins to specific membrane compartments. Here, we show that potassium channels and …

Ultraviolet (UV) light is dangerous to unpigmented organisms, inducing photodamage of
cells and DNA. The transparent nematode Caenorhabditis elegans, despite having no eyes …

Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the
Huntingtin gene (HTT). Reducing the expression of mutant HTT is an obvious therapeutic …

The Wnt signaling pathway is a highly conserved cell signaling pathway that regulates cell
fate determination and maintains adult stem cell populations, and when misregulated …

Sensory axons from functionally related neurons often project to similar regions in the
central nervous system (CNS). Various cell-cell interactions and activity-dependent …