Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

Elastin‐like polypeptides: biomedical applications of tunable biopolymers

SR MacEwan, A Chilkoti - Peptide Science: Original Research …, 2010 - Wiley Online Library
Artificial repetitive polypeptides have grown in popularity as a bioinspired alternative to
synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of …

Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes

JR McDaniel, JA MacKay, FG Quiroz… - …, 2010 - ACS Publications
This paper reports a new strategy, recursive directional ligation by plasmid reconstruction
(PRe-RDL), to rapidly clone highly repetitive polypeptides of any sequence and specified …

Peptide-based biopolymers in biomedicine and biotechnology

D Chow, ML Nunalee, DW Lim, AJ Simnick… - Materials Science and …, 2008 - Elsevier
Peptides are emerging as a new class of biomaterials due to their unique chemical,
physical, and biological properties. The development of peptide-based biomaterials is …

Elastin‐like polypeptides as a purification tag for recombinant proteins

W Hassouneh, T Christensen… - Current protocols in …, 2010 - Wiley Online Library
This unit presents a recombinant protein purification method that employs an elastin‐like
polypeptide (ELP) as a purification tag. ELPs undergo a sharp and reversible phase …

Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application

DM Floss, K Schallau, S Rose-John, U Conrad… - Trends in …, 2010 - cell.com
Elastin-like polypeptides (ELPs) are highly biocompatible and exhibit a potentially highly
useful property: that of a thermally responsive reversible phase transition. These …

Elastin-like polypeptides as a promising family of genetically-engineered protein based polymers

T Kowalczyk, K Hnatuszko-Konka, A Gerszberg… - World Journal of …, 2014 - Springer
Elastin-like polypeptides (ELP) are artificial, genetically encodable biopolymers, belonging
to elastomeric proteins, which are widespread in a wide range of living organisms. They are …

Quantitative model of the phase behavior of recombinant pH-responsive elastin-like polypeptides

JA MacKay, DJ Callahan, KN FitzGerald… - …, 2010 - ACS Publications
Quantitative models are required to engineer biomaterials with environmentally responsive
properties. With this goal in mind, we developed a model that describes the pH-dependent …

Fabricated elastin

GC Yeo, B Aghaei‐Ghareh‐Bolagh… - Advanced …, 2015 - Wiley Online Library
The mechanical stability, elasticity, inherent bioactivity, and self‐assembly properties of
elastin make it a highly attractive candidate for the fabrication of versatile biomaterials. The …

Elastin‐like polypeptides: A strategic fusion partner for biologics

A Yeboah, RI Cohen, C Rabolli… - Biotechnology and …, 2016 - Wiley Online Library
Elastin‐like peptides (ELPs) are derivatives of tropoelastin with a unique property that allows
them to stay soluble below a certain critical temperature but reversibly form aggregates …