Bone is an outstanding, well-designed composite. It is constituted by a multi-level structure
wherein its properties and behavior are dependent on its composition and structural …

Abstract Purpose of Review The goal of this review is to summarize recent findings related to
modifications in osteocyte lacunar and canalicular morphology due to physiological and …

Previous studies have demonstrated that osteocyte lacunar morphology and perilacunar
bone tissue properties undergo alterations due to physiological and pathological processes …

Scaffolds are an essential component of bone tissue engineering. They provide support and
create a physiological environment for cells to proliferate and differentiate. Bone allografts …

Clinical studies indicate that microvascular disease (MVD) affects bone microstructure and
decreases bone strength in type 2 diabetes mellitus (T2D). Osteocytes are housed in small …

Physiological and pathological processes such as aging, diseases, treatments, and lactation
can alter lacunar–canalicular network (LCN) morphology and perilacunar region properties …

Cellular communication in the mechanosensory osteocyte Lacuno‐Canalicular Network
(LCN) regulates bone tissue remodeling throughout life. Age‐associated declines in LCN …

Abstract Purpose of Review To revisit the bone tissue mechanotransduction mechanisms
behind the bone tissue response to mechanical loading and, within this context, explore the …

Understanding the genetic basis of cortical bone traits can allow for the discovery of novel
genes or biological pathways regulating bone health. Mice are the most widely used …

The lacunar morphology and perilacunar tissue properties of osteocytes in bone can vary
under different physiological and pathological conditions. How these alterations collectively …