Selective nutrient transport in bacteria: multicomponent transporter systems reign supreme
Multicomponent transporters are used by bacteria to transport a wide range of nutrients.
These systems use a substrate-binding protein to bind the nutrient with high affinity and then …
These systems use a substrate-binding protein to bind the nutrient with high affinity and then …
TRAPs: the 'elevator-with-an-operator'mechanism
Tripartite ATP-independent periplasmic (TRAP) transporters are nutrient-uptake systems
found in bacteria and archaea. These evolutionary divergent transporter systems couple a …
found in bacteria and archaea. These evolutionary divergent transporter systems couple a …
Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut
Sialic acid (N-acetylneuraminic acid (Neu5Ac)) is commonly found in the terminal location of
colonic mucin glycans where it is a much-coveted nutrient for gut bacteria, including …
colonic mucin glycans where it is a much-coveted nutrient for gut bacteria, including …
Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet‐Induced Obese Mice
Scope The polyphenol xanthohumol (XN) improves dysfunctional glucose and lipid
metabolism in diet‐induced obesity animal models. Because XN changes intestinal …
metabolism in diet‐induced obesity animal models. Because XN changes intestinal …
“Just a spoonful of sugar...”: import of sialic acid across bacterial cell membranes
Eukaryotic cell surfaces are decorated with a complex array of glycoconjugates that are
usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon …
usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon …
[HTML][HTML] On the function of TRAP substrate-binding proteins: conformational variation of the sialic acid binding protein SiaP
Tripartite ATP-independent periplasmic (TRAP) transporters are analogous to ABC
transporters in that they use a substrate-binding protein to scavenge metabolites (eg, N …
transporters in that they use a substrate-binding protein to scavenge metabolites (eg, N …
Selective point-of-care detection of pathogenic bacteria using sialic acid functionalized gold nanoparticles
In resource-limited settings, fast and simple point-of-need tests should facilitate healthcare
providers the identification of pathogens avoiding empirical suboptimal treatments with …
providers the identification of pathogens avoiding empirical suboptimal treatments with …
The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with
negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived …
negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived …
Multi-wavelength analytical ultracentrifugation as a tool to characterise protein–DNA interactions in solution
Understanding how proteins interact with DNA, and particularly the stoichiometry of a protein–
DNA complex, is key information needed to elucidate the biological role of the interaction, eg …
DNA complex, is key information needed to elucidate the biological role of the interaction, eg …
Functional and solution structure studies of amino sugar deacetylase and deaminase enzymes from Staphylococcus aureus
N‐Acetylglucosamine‐6‐phosphate deacetylase (NagA) and glucosamine‐6‐phosphate
deaminase (NagB) are branch point enzymes that direct amino sugars into different …
deaminase (NagB) are branch point enzymes that direct amino sugars into different …