Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Gallstones grow inside the gallbladder or biliary tract. These stones can be asymptomatic or
symptomatic; only gallstones with symptoms or complications are defined as gallstone …

Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …

The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that
efflux various substrates across extra‐and intracellular membranes. Mutations in ABC genes …

Alcohol misuse is the leading cause of cirrhosis and the second most common indication for
liver transplantation in the Western world,,. We performed a genome-wide association study …

Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that …

Diseases of the gallbladder are common and costly. The best epidemiological screening
method to accurately determine point prevalence of gallstone disease is ultrasonography …

Although in the past century mortality in West Germany decreased similarly as in other
Western nations, these changes were less pronounced in East Germany. 1, 2 After German …

An update on the pathogenesis of cholesterol gallstone disea... : Current Opinion in
Gastroenterology An update on the pathogenesis of cholesterol gallstone disease : Current …

The last few years have seen extensive efforts to catalogue human genetic variation and
correlate it with phenotypic differences. Most common SNPs have now been assessed in …