Mastocytosis is a neoplasm characterized by a clonal proliferation of mast cells, which
accumulate in one or multiple organs, associated with an extremely heterogeneous clinical …

Based on new data and increased understanding of disease molecular genetics, the
international consensus classification (ICC) has made several changes in the diagnosis and …

The measurement of mast cell tryptase levels in serum has found utility in the diagnosis and
management of both clonal mast cell disorders and severe mast cell–dependent systemic …

The association between Hymenoptera venom‐triggered anaphylaxis (HVA) and clonal
mast cell‐related disorders (cMCD) has been known for decades. However, recent …

Mast cells (MCs) are stationary cells and are present in all vascularized tissues. 1–4
Although their physiologic role is thought to be supporting innate immunity, wound healing …

Simple Summary The term mastocytosis denotes a heterogeneous group of rare disorders
characterized by abnormal accumulation and activation of mast cells in various organs …

Our knowledge of biology and mast cell (MC) function, as well as disorders associated with
the pathologic activation of MCs, has evolved over the last few decades. Anaphylaxis, mast …

Patients with Hymenoptera venom allergy (HVA), especially those with severe anaphylaxis,
frequently have concomitant clonal mast cell disease (MCD) in the form of systemic …

Timely diagnosis of systemic mastocytosis (SM) remains challenging because of care
heterogeneity. We implemented a standardized approach for SM screening and diagnosis …

Abstract Purpose of Review The current article aims to provide a comprehensive update on
diagnostic criteria for mast cell activation syndrome (MCAS), addressing challenges in …