Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …

Abstract Background. Carbapenem-resistant Enterobacteriaceae (CRE) are associated with
considerable mortality. As mechanisms of carbapenem resistance are heterogeneous, it is …

Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics
are continually changing. Extraintestinal E. coli infections, such as urinary tract infections …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

The management of infections due to Klebsiella pneumoniae has been complicated by the
emergence of antimicrobial resistance, especially to carbapenems. Resistance to …

This article provides a comprehensive review of currently available treatment options for
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …

Despite being members of gut microbiota, Enterobacteriaceae are associated with many
severe infections such as bloodstream infections. The β-lactam drugs have been the …

The rapid and global spread of antimicrobial-resistant organisms in recent years has been
unprecedented. Although resistant gram-positive infections have been concerning to …

ABSTRACT Ceftazidime-avibactam (CAZ-AVI) is a recently approved β-lactam–β-lactamase
inhibitor combination with the potential to treat serious infections caused by carbapenem …