Cervical carcinoma: oncobiology and biomarkers

LV Volkova, AI Pashov, NN Omelchuk - International journal of molecular …, 2021 - mdpi.com
Cervical cancer is one of the most common types of carcinomas causing morbidity and
mortality in women in all countries of the world. At the moment, the oncology, oncobiology …

The p53 family member p73 in the regulation of cell stress response

JM Rozenberg, S Zvereva, A Dalina, I Blatov, I Zubarev… - Biology direct, 2021 - Springer
During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Clinicopathologic and molecular markers in cervical carcinoma: a prospective cohort study

MK Halle, AI Ojesina, H Engerud, K Woie… - American journal of …, 2017 - Elsevier
Background Cervical cancer is a major health problem worldwide. Identification of effective
clinicopathologic and molecular markers is vital to improve treatment stratification …

[HTML][HTML] Advancements and perspectives of RBX2 as a molecular hallmark in cancer

Y Tao, L Dai, W Liang, X Li, Y Lyu, J Li, Z Li, Z Shi… - Gene, 2024 - Elsevier
Cancer is a challenging issue for human health. One of the key methods to address this
issue is by comprehending the molecular causes of tumors and creating medications that …

Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis

M Tan, J Xu, J Siddiqui, F Feng, Y Sun - Molecular cancer, 2016 - Springer
Abstract Background SAG (Sensitive to Apoptosis Gene), also known as RBX2, ROC2 or
RNF7, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our recent …

Dual role of p73 in cancer microenvironment and DNA damage response

JM Rozenberg, S Zvereva, A Dalina, I Blatov, I Zubarev… - Cells, 2021 - mdpi.com
Understanding the mechanisms that regulate cancer progression is pivotal for the
development of new therapies. Although p53 is mutated in half of human cancers, its family …

The prognostic value of p53 expression for patients with cervical cancer: a meta analysis

R Zhou, C Wei, J Liu, Y Luo, W Tang - European Journal of Obstetrics & …, 2015 - Elsevier
Objective A number of studies have evaluated the association of p53 expression with the
cervical cancer clinical outcome, but the results were inconsistent. Study design Electronic …

The role of the PTEN/mTOR axis in clinical response of rectal cancer patients

O Orun, S Özden, O Kılınç, P Mega Tiber… - Molecular Biology …, 2022 - Springer
Background Preoperative chemoradiotherapy has long been accepted as a method to
improve survival and lifetime quality of rectal cancer patients. However, physiologic effects of …

Characterization of synergistic anti-tumor effects of doxorubicin and p53 via graphene oxide-polyethyleneimine nanocarriers

B Xie, J Yi, J Peng, X Zhang, L Lei, D Zhao, Z Lei… - Journal of materials …, 2017 - Elsevier
Co-delivery of chemical drugs and therapeutic genes for synergistic therapy provides a
promising strategy to treat devastating diseases. However, the real-time coordination …

[HTML][HTML] Transgenic expression of Sag/Rbx2 E3 causes early stage tumor promotion, late stage cytogenesis and acinar loss in the Kras–PDAC model

Q Zhang, D Wei, M Tan, H Li, MA Morgan, Y Sun - Neoplasia, 2020 - Elsevier
Abstract SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING
component of CRL (Cullin-RING ligase), required for its activity. Our previous studies …