Deep learning for reconstructing protein structures from cryo-EM density maps: Recent advances and future directions
Abstract Cryo-Electron Microscopy (cryo-EM) has emerged as a key technology to determine
the structure of proteins, particularly large protein complexes and assemblies in recent …
the structure of proteins, particularly large protein complexes and assemblies in recent …
De novo atomic protein structure modeling for cryoEM density maps using 3D transformer and HMM
Accurately building 3D atomic structures from cryo-EM density maps is a crucial step in cryo-
EM-based protein structure determination. Converting density maps into 3D atomic …
EM-based protein structure determination. Converting density maps into 3D atomic …
Novel artificial intelligence-based approaches for ab initio structure determination and atomic model building for cryo-electron microscopy
MC DiIorio, AW Kulczyk - Micromachines, 2023 - mdpi.com
Single particle cryo-electron microscopy (cryo-EM) has emerged as the prevailing method
for near-atomic structure determination, shedding light on the important molecular …
for near-atomic structure determination, shedding light on the important molecular …
A large expert-curated cryo-EM image dataset for machine learning protein particle picking
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structures of
biological macromolecular complexes. Picking single-protein particles from cryo-EM …
biological macromolecular complexes. Picking single-protein particles from cryo-EM …
CryoTransformer: a transformer model for picking protein particles from Cryo-EM micrographs
Motivation Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the
structures of large protein complexes. Picking single protein particles from cryo-EM …
structures of large protein complexes. Picking single protein particles from cryo-EM …
Cryo2structdata: A large labeled cryo-em density map dataset for ai-based modeling of protein structures
The advent of single-particle cryo-electron microscopy (cryo-EM) has brought forth a new
era of structural biology, enabling the routine determination of large biological molecules …
era of structural biology, enabling the routine determination of large biological molecules …
A review of biophysical strategies to investigate protein-ligand binding: What have we employed?
Z Zhao, L Zhao, C Kong, J Zhou, F Zhou - International Journal of Biological …, 2024 - Elsevier
The protein-ligand binding frequently occurs in living organisms and plays a crucial role in
the execution of the functions of proteins and drugs. It is also an indispensable part of drug …
the execution of the functions of proteins and drugs. It is also an indispensable part of drug …
[HTML][HTML] De novo atomic protein structure modeling for cryo-em density maps using 3d transformer and hidden markov model
Accurately building three-dimensional (3D) atomic structures from 3D cryo-electron
microscopy (cryo-EM) density maps is a crucial step in the cryo-EM-based determination of …
microscopy (cryo-EM) density maps is a crucial step in the cryo-EM-based determination of …
An outlook on structural biology after A lpha F old: tools, limits and perspectives
S Rosignoli, M Pacelli, F Manganiello… - FEBS Open …, 2024 - Wiley Online Library
AlphaFold and similar groundbreaking, AI‐based tools, have revolutionized the field of
structural bioinformatics, with their remarkable accuracy in ab‐initio protein structure …
structural bioinformatics, with their remarkable accuracy in ab‐initio protein structure …
Accurate cryo-EM protein particle picking by integrating the foundational AI image segmentation model and specialized U-Net
Picking protein particles in cryo-electron microscopy (cryo-EM) micrographs is a crucial step
in the cryo-EM-based structure determination. However, existing methods trained on a …
in the cryo-EM-based structure determination. However, existing methods trained on a …