Interleukin‐33 (IL‐33): a nuclear cytokine from the IL‐1 family

C Cayrol, JP Girard - Immunological reviews, 2018 - Wiley Online Library
Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

Emerging functions of IL-33 in homeostasis and immunity

GK Dwyer, LM D'Cruz… - Annual review of …, 2022 - annualreviews.org
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

Interleukin-33 in tissue homeostasis, injury, and inflammation

AB Molofsky, AK Savage, RM Locksley - Immunity, 2015 - cell.com
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

IL-1 family cytokine regulation of vascular permeability and angiogenesis

E Fahey, SL Doyle - Frontiers in Immunology, 2019 - frontiersin.org
The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory
responses both in response to and acting as danger signals. It has long been established …

Interleukin 33 is a guardian of barriers and a local alarmin

NT Martin, MU Martin - Nature immunology, 2016 - nature.com
Abstract Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing
number of target cells and a plethora of biological functions. Although it has commonalities …

IL-33, an alarmin of the IL-1 family involved in allergic and non allergic inflammation: focus on the mechanisms of regulation of its activity

C Cayrol - Cells, 2021 - mdpi.com
Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) family that is expressed in the
nuclei of endothelial and epithelial cells of barrier tissues, among others. It functions as an …

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

DE Byers, J Alexander-Brett, AC Patel… - The Journal of …, 2013 - Am Soc Clin Investig
Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial
and immune cell function that are driven, at least in part, by infection. Analysis of …

Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia

J Taylor, L Uhl, I Moll, SS Hasan, L Wiedmann… - Nature Cancer, 2023 - nature.com
Cachexia is a major cause of morbidity and mortality in individuals with cancer and is
characterized by weight loss due to adipose and muscle tissue wasting. Hallmarks of white …

A network map of IL-33 signaling pathway

SM Pinto, Y Subbannayya, DAB Rex, R Raju… - Journal of cell …, 2018 - Springer
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central
role in the regulation of immune responses. Its release from epithelial and endothelial cells …

3D curvature-instructed endothelial flow response and tissue vascularization

C Mandrycky, B Hadland, Y Zheng - Science advances, 2020 - science.org
Vascularization remains a long-standing challenge in engineering complex tissues.
Particularly needed is recapitulating 3D vascular features, including continuous geometries …