The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino
acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often …

RagGTPases (Rags) play an essential role in the regulation of cell metabolism by controlling
the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and …

Doxorubicin (DOX) has toxic effects on the heart, causing cardiomyopathy and heart injury,
but the underlying mechanisms of these effects require further investigation. This study …

Abstract Zinc oxide nanoparticles (ZnO NPs) have drawn serious concerns about their
biotoxicity due to their extensive applications in biological medicine, clinical therapeutic …

Heterozygous mutations in the gene encoding RagD GTPase were shown to cause a novel
autosomal dominant condition characterized by kidney tubulopathy and cardiomyopathy …

Transcription factor EB (TFEB) is a member of the microphthalmia-associated transcription
factor/transcription factor E (MiTF/TFE) family and critically involved in the maintenance of …

Transcription factor EB, as a component of the microphthalmia family of transcription factors,
has been demonstrated to be a key controller of autophagy–lysosomal biogenesis …

The Ras-related GTP-binding protein D (RRAGD) gene plays a crucial role in cellular
processes. Recently, RRAGD variants found in patients have been implicated in a novel …

Background Diabetic encephalopathy (DE) is a complication of type 2 diabetes mellitus
(T2DM) that features Alzheimer's disease (AD)-like pathology, which can be degraded by …

Allelic heterogeneity (AH) has been noted in truncational TTN–associated (TTNtv-
associated) dilated cardiomyopathy (DCM); ie, mutations affecting A-band–encoding exons …