Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …

The p38 MAPK signalling pathway plays an important role in inflammation and other
physiological processes. Specific inhibitors of p38 α and β MAPK block production of the …

The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in the
post-transcriptional regulation of inflammatory genes. p38 has been found to regulate both …

The p38 mitogen-activated protein kinase (MAPK) signaling pathway, acting through the
downstream kinase MK2, regulates the stability of many proinflammatory mRNAs that …

Summry—Deregulation of gene expression is a hallmark of the cancer cell. Acquiring a new
profile of expressed proteins may enable the cell to re‐enter the cell cycle, or give them a …

mRNA turnover is a critical step in the control of gene expression. In mammalian cells, a
subset of mRNAs regulated at the level of mRNA turnover contain destabilizing AU-rich …

Messenger RNA decay is a critical mechanism to control the expression of many
inflammation-and cancer-associated genes. These transcripts are targeted for rapid …

Tristetraprolin (TTP) directs its target AU-rich element (ARE)-containing mRNAs for
degradation by promoting removal of the poly (A) tail. The p38 MAPK pathway regulates …

Toll‐like receptor (TLR) signaling leads to the activation of mitogen‐activated protein kinase
and nuclear factor‐κB signaling pathways. While the upstream signaling events initiated at …

The differential expression of the critical cell cycle control proteins cyclin D1 and c-myc has
been shown to result in Akt-dependent hypersensitivity of tumor cells to mTOR inhibitors. We …