Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

▪ Abstract While still incomplete, the first data concerning the biochemistry of T cell receptor–
ligand interactions in cell-free systems seem to have considerable predictive value …

Recognition by a T-cell antigen receptor (TCP) of peptide complexed with a major histo-
compatibility complex (MHC) molecule occurs through variable loops in the TCP structure …

The central event in the cellular immune response to invading microorganisms is the specific
recognition of foreign peptides bound to major histocompatibility complex (MHC) molecules …

Using a chemically homogeneous radiolabeled peptide of high specific activity (125 I-
QLSPYPFDL, 3.5× 10 18 cpm per mole) we show that at a peptide concentration (5 pM) …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens
in the thymus during maturation and then discriminate between foreign pathogens in the …

Considerable advances have been made in our knowledge of the molecular structure of cell
adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein …

Frank Barlow's magisterial biography, first published in 1970 and now reissued with new
material, rescues Edward the Confessor from contemporary myth and subsequent bogus …

▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …