The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Current and future status of JAK inhibitors
DP McLornan, JE Pope, J Gotlib, CN Harrison - The lancet, 2021 - thelancet.com
An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …
and activator of transcription (STAT) signalling in multiple disease states has led to an …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …
The molecular details of cytokine signaling via the JAK/STAT pathway
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …
induce inflammation and control the immune response. Cytokines are secreted …
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Cytokines signal through cell surface receptor dimers to initiate activation of intracellular
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …
Janus kinases (JAKs). We report the 3.6-angstrom–resolution cryo–electron microscopy …
Rusfertide, a hepcidin mimetic, for control of erythrocytosis in polycythemia vera
M Kremyanskaya, AT Kuykendall… - … England Journal of …, 2024 - Mass Medical Soc
Background Polycythemia vera is a chronic myeloproliferative neoplasm characterized by
erythrocytosis. Rusfertide, an injectable peptide mimetic of the master iron regulatory …
erythrocytosis. Rusfertide, an injectable peptide mimetic of the master iron regulatory …
The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: document summary and in-depth discussion
T Barbui, J Thiele, H Gisslinger, HM Kvasnicka… - Blood cancer …, 2018 - nature.com
The new edition of the 2016 World Health Organization (WHO) classification system for
tumors of the hematopoietic and lymphoid tissues was published in September 2017. Under …
tumors of the hematopoietic and lymphoid tissues was published in September 2017. Under …
Interleukin-6: designing specific therapeutics for a complex cytokine
Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …
functions that include regulation of immune cell proliferation and differentiation …
“Do we know jack” about JAK? A closer look at JAK/STAT signaling pathway
E Bousoik, H Montazeri Aliabadi - Frontiers in oncology, 2018 - frontiersin.org
Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …