Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

Pathogenesis and management of traumatic brain injury (TBI): role of neuroinflammation and anti-inflammatory drugs

S Kalra, R Malik, G Singh, S Bhatia, A Al-Harrasi… - …, 2022 - Springer
Traumatic brain injury (TBI) is an important global health concern that represents a leading
cause of death and disability. It occurs due to direct impact or hit on the head caused by …

Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injury

E Bar-Kochba, MT Scimone, JB Estrada, C Franck - Scientific reports, 2016 - nature.com
Abstract In the United States over 1.7 million cases of traumatic brain injury are reported
yearly, but predictive correlation of cellular injury to impact tissue strain is still lacking …

Traumatic brain injury and the neuronal microenvironment: a potential role for neuropathological mechanotransduction

MA Hemphill, S Dauth, CJ Yu, BE Dabiri, KK Parker - Neuron, 2015 - cell.com
Traumatic brain injury (TBI) is linked to several pathologies for which there is a lack of
understanding of disease mechanisms and therapeutic strategies. To elucidate injury …

RhoA-ROCK signaling as a therapeutic target in traumatic brain injury

S Mulherkar, KF Tolias - Cells, 2020 - mdpi.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which
range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic …

[HTML][HTML] The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation

W Lu, Z Chen, J Wen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
It is widely known that ischemic stroke is the prominent cause of death and disability. To
date, neuroinflammation following ischemic stroke represents a complex event, which is an …

Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip

S Dauth, BM Maoz, SP Sheehy… - Journal of …, 2017 - journals.physiology.org
Brain in vitro models are critically important to developing our understanding of basic
nervous system cellular physiology, potential neurotoxic effects of chemicals, and specific …

Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal …

S Lord-Fontaine, F Yang, Q Diep, P Dergham… - Journal of …, 2008 - liebertpub.com
Spinal cord injury (SCI) leads to robust Rho activation at the lesion site. Here, we
demonstrate that BA-210, a cell-permeable fusion protein derived from C3 transferase …

[PDF][PDF] Diverse roles of Rho family GTPases in neuronal development, survival, and death

DA Linseman, FA Loucks - Front Biosci, 2008 - academia.edu
Introduction 3. Rho GTPase effectors 3.1. Rac/Cdc42/PAK 3.2. Rho/ROCK 3.3. Cdc42/ACK
4. Rho GTPases, neuronal growth cone dynamics, and dendritic spine morphogenesis 5 …