Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Magnetic hyperthermia (MHT) is a therapeutic modality for the treatment of solid tumors that
has now accumulated more than 30 years of experience. In the ongoing MHT clinical trials …

Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment.
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …

Pathways that sense a reduction in available oxygen are critical in the adaptation to lower
oxygen tensions at high altitude. Alterations in this system can contribute to the …

Adaptation of cancer cells to their microenvironment is an important driving force in the
clonal selection that leads to invasive and metastatic disease. O 2 concentrations are …

Although used in academic research for several decades, 3D culture models have long
been regarded expensive, cumbersome and unnecessary in drug development processes …

Metastasis is not the result of a random event, as cancer cells can sustain and proliferate
actively only in a suitable tissue microenvironment and then form metastases. Since Dr …

Deletions and duplications of chromosomal segments (copy number variants, CNVs) are a
major source of variation between individual humans and are an underlying factor in human …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …