Publisher Summary This chapter summarizes recent information on the function of high-
mobility-group (HMG) proteins. Advances in this field were made primarily by elucidating the …

Cytogenetics of Bone and Soft Tissue Tumors [1]. In view of the remarkable developments in
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …

GROWTH is one of the fundamental aspects in the development of an organism. Classical
genetic studies have isolated four viable, spontaneous mouse mutants1 disrupted in growth …

We recently showed that the 1.7 megabase multiple aberration region (MAR) on human
chromosome 12q15 harbours recurrent breakpoints frequently found in a variety of benign …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The
first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing …

Lipomas are one of the most common mesenchymal neoplasms in humans. They are
characterized by consistent cytogenetic aberrations involving chromosome 12 in bands q14 …

Atypical lipomatous tumours (ALTs) represent a distinctive subset of mesenchymal
neoplasms featuring mature adipocytic differentiation. Most ALTs are characterized …

The altered form of the high-mobility group A2 (HMGA2) gene is somehow related to the
generation of human benign and malignant tumours of mesenchymal origin. However, only …

The structural characteristics of the three nuclear phosphoproteins of the high mobility group
A family are outlined and related to their participation in chromatin structure alteration in …