Palmitoylated transmembrane adaptor proteins in leukocyte signaling
O Stepanek, P Draber, V Horejsi - Cellular Signalling, 2014 - Elsevier
Transmembrane adaptor proteins (TRAPs) are structurally related proteins that have no
enzymatic function, but enable inducible recruitment of effector molecules to the plasma …
enzymatic function, but enable inducible recruitment of effector molecules to the plasma …
[HTML][HTML] Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes
Secreted Wnts play crucial roles in synaptogenesis and synapse maintenance, but
endogenous factors promoting synapse elimination in central neurons remain unknown …
endogenous factors promoting synapse elimination in central neurons remain unknown …
[HTML][HTML] Variant-to-gene-mapping analyses reveal a role for the hypothalamus in genetic susceptibility to inflammatory bowel disease
C Lasconi, MC Pahl, DL Cousminer, CA Doege… - Cellular and Molecular …, 2021 - Elsevier
Background & Aims Inflammatory bowel disease (IBD) is a polygenic disorder characterized
principally by dysregulated inflammation impacting the gastrointestinal tract. However, there …
principally by dysregulated inflammation impacting the gastrointestinal tract. However, there …
pTRAPs: Transmembrane adaptors in innate immune signaling
Transmembrane adaptor proteins (TRAPs) are protein scaffolds and signaling regulators
with established roles in signal-induced activation of lymphocytes. A subset of the TRAP …
with established roles in signal-induced activation of lymphocytes. A subset of the TRAP …
Synaptonuclear messenger PRR 7 inhibits c‐Jun ubiquitination and regulates NMDA‐mediated excitotoxicity
Elevated c‐Jun levels result in apoptosis and are evident in neurodegenerative disorders
such as Alzheimer's disease and dementia and after global cerebral insults including stroke …
such as Alzheimer's disease and dementia and after global cerebral insults including stroke …
Functional roles of folic acid in alleviating dexamethasone‐induced fatty liver syndrome in laying hens
X Sun, J Ma, C Wang, Z Ren, X Yang… - Animal Research and …, 2024 - Wiley Online Library
Fatty liver syndrome (FLS) poses a threat to the poultry industry due to its high occurrence
and mortality rate. Folic acid (FA) is a coenzyme crucial for one‐carbon metabolism …
and mortality rate. Folic acid (FA) is a coenzyme crucial for one‐carbon metabolism …
[HTML][HTML] LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane
Transmembrane adaptor proteins are membrane-anchored proteins consisting of a short
extracellular part, a transmembrane domain, and a cytoplasmic part with various protein …
extracellular part, a transmembrane domain, and a cytoplasmic part with various protein …
[HTML][HTML] Transforming Growth Factor Beta (TGFβ1) and Epidermal Growth Factor (EGF) as Biomarkers of Leishmania (V) braziliensis Infection and Early Therapeutic …
A Montoya, L Yepes, A Bedoya, R Henao… - Frontiers in cellular …, 2018 - frontiersin.org
Introduction: In cutaneous leishmaniasis, the host immune response is responsible for the
development of skin injuries but also for resolution of the disease especially after …
development of skin injuries but also for resolution of the disease especially after …
[HTML][HTML] Normal development and function of T cells in proline rich 7 (Prr7) deficient mice
Transmembrane adaptor proteins (TRAPs) are important organisers for the transduction of
immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell receptor (TCR) …
immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell receptor (TCR) …
[HTML][HTML] The transmembrane region is responsible for targeting of adaptor protein LAX into “heavy rafts”
Background The importance of membrane compartmentalization into specific membrane
microdomains has been shown in many biological processes such as immunoreceptor …
microdomains has been shown in many biological processes such as immunoreceptor …