Effects of reactive oxygen and nitrogen species on TrkA expression and signalling: implications for proNGF in aging and Alzheimer's disease

E Kropf, M Fahnestock - Cells, 2021 - mdpi.com
Nerve growth factor (NGF) and its precursor form, proNGF, are critical for neuronal survival
and cognitive function. In the brain, proNGF is the only detectable form of NGF …

Alpha-synuclein toxicity on protein quality control, mitochondria and endoplasmic reticulum

TQ Melo, SJ Copray, MFR Ferrari - Neurochemical research, 2018 - Springer
Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters
containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and …

A new zebrafish model to measure neuronal α-synuclein clearance in vivo

A Lopez, A Gorb, N Palha, A Fleming, DC Rubinsztein - Genes, 2022 - mdpi.com
The accumulation and aggregation of α-synuclein (α-SYN) is a common characteristic of
synucleinopathies, such as Parkinson's Disease (PD), Dementia with Lewy Bodies (DLB) or …

The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease

HY Li, DS Liu, YB Zhang, H Rong, XJ Zhang - Biophysical Chemistry, 2023 - Elsevier
Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the
hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy …

Overexpression of kinesin superfamily motor proteins in Alzheimer's disease

K Hares, JS Miners, AJ Cook, C Rice… - Journal of …, 2017 - content.iospress.com
Defects in motor protein-mediated neuronal transport mechanisms have been implicated in
a number of neurodegenerative disorders but remain relatively little studied in Alzheimer's …

Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease

TQ Melo, KC van Zomeren, MFR Ferrari… - Experimental brain …, 2017 - Springer
The formation of oligomers and aggregates of overexpressed or mutant α-synuclein play a
role in the degeneration of dopaminergic neurons in Parkinson's disease by causing …

Circ_0049472 regulates the damage of Aβ-induced SK-N-SH and CHP-212 cells by mediating the miR-107/KIF1B axis

C Zeng, H Xing, M Chen, L Chen, P Li, X Wu… - Experimental Brain …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that seriously affects the life and
health of the elderly. Studies have found that circular RNAs (circRNAs) are associated with …

Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer's disease

SSK Durairajan, K Selvarasu, AK Singh… - Frontiers in Cellular …, 2024 - frontiersin.org
Alzheimer's disease (AD) is marked by the gradual and age-related deterioration of nerve
cells in the central nervous system. The histopathological features observed in the brain …

Docosahexaenoic acid protection in a rotenone induced Parkinson's model: Prevention of tubulin and synaptophysin loss, but no association with mitochondrial …

N Serrano-García, F Fernández-Valverde… - Neurochemistry …, 2018 - Elsevier
Rotenone, a classic mitochondrial complex I inhibitor, leads to dopaminergic neuronal death
resulting in a Parkinson's-like-disease. Docosahexaenoic acid (DHA) has shown …

An exploratory study on the ability of manganese to supplement rotenone neurotoxicity in rats

MT Ibarra-Gutiérrez, N Serrano-García… - Brain Research, 2024 - Elsevier
Parkinson's disease (PD) is a complex disorder, primarily of idiopathic origin, with
environmental stressors like rotenone and manganese linked to its development. This study …